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Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity Published June 22, 2025 N Engl J Med 2025;393:635-647 DOI: 10.1056/NEJMoa2502081 Abstract Background Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg has shown promising results in early-phase trials